The PCs are a Masquerade breach clean-up team. Five PCs, one for each clan and one for each covenant. (I would do up some pregens for pick-up purposes.) Each of them has gotten into some trouble with the city's authorities, not quite severe enough to warrant immediate destruction, but they're all very much on probation. If they do a good job at this task, they'll earn their way back into favor.
Me: Leverage After Dark. 
Sean: was thinking Vampire: The Mission Impossible.
Me: *nod* Po-TAY-to, po-TAH-to.
The caper angle allows for plenty of fun, and the facts of clean-up duty mean opportunity to look into all kinds of slices through the routine unlife of the city, from comedy to tragedy. So it'd be an excuse to use all that neat Damnation City stuff (and Immortal Sinners, and...) in bite-sized chunks.
I recently encountered the suggestion of just tossing out the whole damn combat system and doing it with regular opposed skill checks, assessing impairments based on outcomes. That would work well for me; I'd rather put the detail into stealth and the like.
The thought of all this amuses me greatly.
